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Wet granulation is broken down into three rate processes that are often inseparable from each other, hindering characterization of the relationship between operating conditions and product properties. Single-drop granulation is a form of drop-controlled nucleation intended to isolate the Wetting & Nucleation rate process. In this work, single-dropped granules (pre-nucleated granules) were charged to a mixer granulator under varied conditions to observe how the individual rate processes and resulting granulated product were affected by various pre-nucleation conditions. Batches with larger fractions of pre-nucleated granules tended to produce a larger granule size than batches with few or no pre-nucleated granules. A clear and consistent trend of deviation from traditional granulation results is observed. Liquid to solid ratio is ruled out as a sole cause for the deviation, indicating that pre-nucleation may have applications in granular material production with respect to liquid dosing in granules, granule size control, and efficient material usage.